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研究方向

医学为导向的化学生物学研究;课题组主要围绕以下两方面开展基础与应用研究:

  • 靶向重要生命与疾病过程的糖、多肽等分子探针和自组装材料构建;

  • 临床医学为导向的新型光学体外诊断试剂盒研发。

Research Interest

Our research interest spans chemistry, biology, materials science and medical sciences, mainly focusing on the following two subjects:

  • Fluorescence-based molecular probes for precise biosensing and bioimaging.

  • Development of novel diagnostic and theranostic tools for human fatal diseases.

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课题组简介

课题组依托华东理工大学Feringa诺贝尔科学家联合研究中心田禾院士团队,研究方向跨化学、材料科学、生物学、临床医学等多个基础学科领域,与中国人民解放军海军军医大学附属东方肝胆外科医院王红阳院士团队,中国科学院上海药物研究所、中国科学院上海巴斯德研究所等国内顶尖生物医学平台开展跨学科研究。诚挚欢迎对通过化学手段解决生命科学疑难问题,以及我国自主知识产权体外试剂盒具趣和探索精神的同学加入课题组课题组培养硕、博研究生中已有多人获上海市和校级优秀博士学位论文,研究生国家奖学金和成思危校长奖等各类荣誉奖励。

招生专业

  • 博士第一招生专业:应用化学

  • 硕士第一招生专业:应用化学

  • 硕士第二招生专业:制药工程

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Key Publications

Research papers
An ESIPT Probe for the Ratiometric Imaging of Peroxynitrite Facilitated by Binding to Aβ-Aggregates.
A. C. Sedgwick, W.-T. Dou, J.-B. Jiao, L. Wu, G. T. Williams, A. T. A. Jenkins, S. D. Bull, J. L. Sessler*, X.-P. He*, and T. D. James*
J. Am. Chem. Soc. 2018140, 14267-14271.

Photo-controlled fluorescence “double-check” bioimaging enabled by a glycoprobe-protein hybrid.
F. Xu, H.-H. Han, J. Zhang*, X.-P. He*, B. L. Feringa, H. Tian*
J. Am. Chem. Soc. 2018, 140, 8671-8674.

Supramolecular nanostructures of structurally defined graphene nanoribbons in aqueous phase.
Y. Huang, W.-T. Dou, F. Xu, H.-B. Ru, Q. Gong, D. Wu, D. Yan, H. Tian, X.-P. He*, Y. Mai*, X. Feng
Angew. Chem. Int. Ed. 2018, 57, 3366-3371. (Very Important Paper)

Remote light-controlled intracellular target recognition by photochromic fluorescent glycoprobes.
J. Zhang, Y. Fu, H.-H. Han, Y. Zang, J. Li*, X.-P. He*, B. L. Feringa, H. Tian*
Nat. Commun. 2017, 8, 987. (ESI highly cited paper; ESI hot paper; Highlighted by Sci. China Chem.)

Fluorogenic 2D peptidosheet unravels CD47 as a potential biomarker for profiling hepatocellular carcinoma and cholangiocarcinoma tissues.
Y.-H. Ma, W.-T. Dou, Y.-F. Pan, L.-W. Dong, Y.-X. Tan, X.-P. He*, H. Tian, H.-Y. Wang*
Adv. Mater. 2017, 29, 1604253. (ESI highly cited paper; Inside back cover)

Rapid identification of the receptor-binding specificity of influenza A viruses by fluorogenic glycofoldamers.
X.-P. He*, Y.-L. Zeng, X.-Y. Tang, N. Li, D.-M. Zhou*, G.-R. Chen, H. Tian*
Angew. Chem. Int. Ed. 2016, 55, 13995-13999. (ESI hot paper; Inside back cover)

Targeted intracellular production of reactive oxygen species by a 2D molybdenum disulfide glycosheet.
D.-K. Ji, Y. Zhang, Y. Zang, J. Li*, G.-R. Chen, X.-P. He*, H. Tian
Adv. Mater. 2016, 28, 9356-9363. (ESI hot paper)

Simultaneous detection of diverse glycoligand–receptor recognitions using a single-excitation, dual-emission graphene composite.
D.-K. Ji, G.-R. Chen, X.-P. He*, H. Tian
Adv. Funct. Mater. 2015, 25, 3483-3487. (Back cover)

Fluorogenic probing of specific recognitions between sugar ligands and glycoprotein receptors on cancer cells by an economic graphene nanocomposite.
H.-L. Zhang, X.-L. Wei, Y. Zang, J.-Y. Cao, S. Liu, X.-P. He*, Q. Chen, Y.-T. Long, J. Li*, G.-R. Chen*, K. Chen
Adv. Mater. 2013, 25, 4097-4101. (Front cover)

Epimeric monosaccharide-quinone hybrids on gold electrodes toward the electrochemical probing of specific carbohydrate–protein recognitions.
X.-P. He, X.-W. Wang, X.-P. Jin, H. Zhou, X.-X. Shi, G.-R. Chen, Y.-T. Long*
J. Am. Chem. Soc. 2011, 133, 3649-3657.

Review papers
Fluorogenic probes for disease-relevant enzymes.
J. Zhang, X. Chai, X.-P. He*, H.-J. Kim*, J. Yoon*, H. Tian
Chem. Soc. Rev. 2019. DOI: 10.1039/C7CS00907K

Excited-state intramolecular proton-transfer (ESIPT) based fluorescence sensors and imaging agents.
A. C. Sedgwick, L. Wu, H.-H. Han, S. D. Bull*, X.-P. He*, T. D. James*, J. L. Sessler*, B.- Z. Tang*, H. Tian*, J. Yoon*
Chem. Soc. Rev. 2018, 47, 8842-8880.

Lightening up membrane receptors with fluorescent molecular probes and supramolecular materials.
X.-P. He, H. Tian*
Chem 2018, 4, 246-268. (ESI highly cited paper; Invited review)

Multiplexed photoluminescent sensors: Towards improved disease diagnostics.
X.-P. He*, X.-L. Hu, T. D. James*, J. Yoon*, H. Tian*
Chem. Soc. Rev. 2017, 46, 6687-6696. (Tutorial review)

Fluorescent glycoprobes: A sweet addition for improved sensing.
X.-P. He, Y. Zang, T. D. James*, J. Li*, G.-R. Chen*, J. Xie*
Chem. Commun. 2017, 53, 82-90. (ESI highly cited paper; Feature article)

Photoluminescence architectures for disease diagnosis: From graphene to thin-layer transition metal dichalcogenides and oxides.
X.-P. He, H. Tian*
Small 2016, 12, 6562-6567. (ESI highly cited paper; Highlighted by MaterialsViews China)

Probing disease-related proteins with fluorogenic composite materials.
X.-P. He, Y. Zang, T. D. James, J. Li*, G.-R. Chen*
Chem. Soc. Rev. 2015, 44, 4239-4248. (ESI highly cited paper; Tutorial review)

Xiao-Peng He

Xiao-Peng He (Franck) received his BSc in Applied Chemistry (2006) and PhD in Pharmaceutical Engineering (2011) with Prof. Xiaoxin Shi and Prof. Yi-Tao Long from ECUST. Sponsored by the French Embassy, He completed a co-tutored doctoral program at ENS Cachan (France) from July 2008 to February 2009 under the supervision of Prof. Juan Xie. Then he carried out his postdoctoral research with Prof. Kaixian Chen (SIMM, CAS) at ECUST from 2011 to 2013. He’s now a professor at School of Chemistry and Molecular Engineering, ECUST, where his research interests span chemical glycobiology to fluorescent molecular probes for disease diagnostics and theranostics. Prof. He has co-authored over 100 peer-reviewed papers and is co-inventor of 8 Chinese patents.

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