Home 2021-02-12T19:24:10+00:00



  • 靶向重要生命与疾病过程的糖、多肽等分子探针和自组装材料构建;

  • 临床医学为导向的新型光学体外诊断试剂盒研发。

Research Interest

Our research interest spans chemistry, biology, materials science and medical sciences, mainly focusing on the following two subjects:

  • Fluorescence-based molecular probes for precise biosensing and bioimaging.

  • Development of novel diagnostic and theranostic tools for human fatal diseases.

Join Us




  • 博士第一招生专业:应用化学

  • 博士第二招生专业:精细合成化学与分子工程

  • 硕士第一招生专业:应用化学

  • 硕士第二招生专业:制药工程

Join Us

Representative publications

Lightening up Membrane Receptors with Fluorescent Molecular Probes and Supramolecular Materials.
X.-P. He, H. Tian*
Chem 2018, 4, 246-268. (ESI highly cited paper; Invited review)

Remote Light-Controlled Intracellular Target Recognition by Photochromic Fluorescent Glycoprobes.
J. Zhang, Y. Fu, H.-H. Han, Y. Zang, J. Li*, X.-P. He*, B. L. Feringa, H. Tian*
Nat. Commun. 2017, 8, 987. (ESI highly cited paper; ESI hot paper; Highlighted by Sci. China Chem.)

Deferasirox (ExJade): An FDA-Approved AIEgen Platform with Unique Photophysical Properties.
A. C. Sedgwick, K.-C. Yan, D. N. Mangel, Y. Shang, A. Steinbrueck, H.-H. Han, J. T. Brewster II, X.-L. Hu, D. W. Snelson, V. M. Lynch, H. Tian, X.-P. He*, J. L. Sessler*
J. Am. Chem. Soc.  2021143, 1278-1283.

A Photochromic Fluorescent Probe Strategy for the Superresolution Imaging of Biologically Important Biomarkers.
X. Chai, H.-H. Han, A. C. Sedgwick, N. Li, Y. Zang, T. D. James, J. Zhang*, X.-L. Hu, Y. Yu, Y. Li, Y. Wang, J. Li*, X.-P. He*, H. Tian
J. Am. Chem. Soc.  2020, 142, 18005-18013.

Manganese(II) Texaphyrin: A Paramagnetic Photoacoustic Contrast Agent Activated by Near-IR Light.
Y. Ren, A. C. Sedgwick, J. Chen, G. Thiabaud, C. V. Chau, J. An, J. F. Arambula, X.-P. He, J. S. Kim*, J. L. Sessler*, C. Liu*
J. Am. Chem. Soc.  2020, 142, 16156-16160.

Cyclodextrin-Based Peptide Self-Assemblies (Spds) That Enhance Peptide-Based Fluorescence Imaging and Antimicrobial Efficacy.
J.-B. Jiao, G.-Z. Wang, X.-L. Hu, Y. Zang, S. Maisonneuve, A. C. Sedgwick, J. L. Sessler*, J. Xie*, J. Li*, X.-P. He*,  H. Tian
J. Am. Chem. Soc. 
2020, 142, 1925-1932.

A Supramolecular‐Based Dual‐Wavelength Phototherapeutic Agent with Broad Spectrum Antimicrobial Activity against Drug Resistant Bacteria.
Z.-H. Yu, X. Li, F. Xu, X.-L. Hu, J. Yan, N. Kwon, G.-R. Chen, T. Tang, X. Dong, Y. Mai*, D. Chen*, J. Yoon*, X.-P. He*, H. Tian
Angew. Chem. Int. Ed. 2020, 59, 3658-3664.

An ESIPT Probe for the Ratiometric Imaging of Peroxynitrite Facilitated by Binding to Aβ-Aggregates.
A. C. Sedgwick, W.-T. Dou, J.-B. Jiao, L. Wu, G. T. Williams, A. T. A. Jenkins, S. D. Bull, J. L. Sessler*, X.-P. He*, T. D. James*
J. Am. Chem. Soc. 2018140, 14267-14271.

Photo-Controlled Fluorescence “Double-Check” Bioimaging Enabled by a Glycoprobe-protein Hybrid.
Y. Fu, H.-H. Han, J. Zhang*, X.-P. He*, B. L. Feringa, H. Tian*
J. Am. Chem. Soc. 2018, 140, 8671-8674.

Supramolecular Nanostructures of Structurally Defined Graphene Nanoribbons in Aqueous Phase.
Y. Huang, W.-T. Dou, F. Xu, H.-B. Ru, Q. Gong, D. Wu, D. Yan, H. Tian, X.-P. He*, Y. Mai*, X. Feng
Angew. Chem. Int. Ed. 2018, 57, 3366-3371. (Very Important Paper)

Rapid Identification of the Receptor-Binding Specificity of Influenza A Viruses by Fluorogenic Glycofoldamers.
X.-P. He*, Y.-L. Zeng, X.-Y. Tang, N. Li, D.-M. Zhou*, G.-R. Chen, H. Tian*
Angew. Chem. Int. Ed. 2016, 55, 13995-13999. (ESI hot paper; Inside back cover)

Epimeric Monosaccharide-Quinone Hybrids on Gold Electrodes toward the Electrochemical Probing of Specific Carbohydrate–Protein Recognitions.
X.-P. He, X.-W. Wang, X.-P. Jin, H. Zhou, X.-X. Shi, G.-R. Chen, Y.-T. Long*
J. Am. Chem. Soc. 2011, 133, 3649-3657.

Key Review Papers

Förster Resonance Energy Transfer (FRET)-Based Small-Molecule Sensors and Imaging Agents.
L. Wu, C. Huang*, B. P. Emery, A. C. Sedgwick, S. D. Bull, X.-P. He, H. Tian*, J. Yoon*, J. L. Sessler*, T. D. James*
Chem. Soc. Rev. 202049, 5110-5139.

Transition Metal Chelators, Pro-Chelators, and Ionophores as Small Molecule Cancer Chemotherapeutic Agents.
A. Steinbrueck, A. C. Sedgwick, J. T. Brewster II, K.-C. Yan, Y. Shang, D. M. Knoll, G. I. Vargas-Zúñiga, X.-P. He*, H. Tian*, J. L. Sessler*
Chem. Soc. Rev. 202049, 3726-3747.

Metal-Based Imaging Agents: Progress towards Interrogating Neurodegenerative Disease.
A. C. Sedgwick, J. T. Brewster II, P. Harvey*, D. A. Iovan, G. Smith, X.-P. He*, H. Tian*, J. L. Sessler*, T. D. James*
Chem. Soc. Rev. 202049, 2886-2915.

Fluorescent Glycoconjugates and Their Applications.
B. Thomas, K.-C. Yan, X.-L. Hu, M. Donnier-Maréchal, G.-R. Chen*, X.-P. He*S. Vidal*
Chem. Soc. Rev. 2020, 49, 593-641.

Fluorogenic Probes for Disease-Relevant Enzymes.
J. Zhang, X. Chai, X.-P. He*, H.-J. Kim*, J. Yoon*, H. Tian
Chem. Soc. Rev. 201948, 683-722. (ESI highly cited paper)

Reaction-Based Fluorescent Probes for the Detection and Imaging of Reactive Oxygen, Nitrogen, and Sulfur Species.
L. Wu, A. C. Sedgwick, X. Sun, S. D. Bull, X.-P. He, T. D. James*
Acc. Chem. Res. 201952, 2582-2597.

Excited-State Intramolecular Proton-Transfer (ESIPT) Based Fluorescence Sensors and Imaging Agents.
A. C. Sedgwick, L. Wu, H.-H. Han, S. D. Bull*, X.-P. He*, T. D. James*, J. L. Sessler*, B.- Z. Tang*, H. Tian*, J. Yoon*
Chem. Soc. Rev. 2018, 47, 8842-8880. (ESI highly cited paper; ESI hot paper)

Multiplexed Photoluminescent Sensors: Towards Improved Disease Diagnostics.
X.-P. He*, X.-L. Hu, T. D. James*, J. Yoon*, H. Tian*
Chem. Soc. Rev. 2017, 46, 6687-6696. (Tutorial review)

Fluorescent Glycoprobes: A Sweet Addition for Improved Sensing.
X.-P. He, Y. Zang, T. D. James*, J. Li*, G.-R. Chen*, J. Xie*
Chem. Commun. 2017, 53, 82-90. (ESI highly cited paper; Feature article)

Probing Disease-Related Proteins with Fluorogenic Composite Materials.
X.-P. He, Y. Zang, T. D. James, J. Li*, G.-R. Chen*
Chem. Soc. Rev. 2015, 44, 4239-4248. (ESI highly cited paper; Tutorial review)

Materials-Based Research

Bio-Conjugated Advanced Materials for Targeted Disease Theranostics.
X.-L. Hu, N. Kwon, K.-C. Yan, A. C. Sedgwick, G.-R. Chen, X.-P. He*, T. D. James*, J. Yoon*
Adv. Funct. Mater. 2020, 30, 1907906.

Multivalent Glycosheets for Double Light–Driven Therapy of Multidrug-Resistant Bacteria on Wounds.
X.-L. Hu, L. Chu, X. Dong, G.-R. Chen, T. Tang, D. Chen*, X.-P. He*, H. Tian
Adv. Funct. Mater. 201929, 1806986.

Sensors, Imaging Agents, and Theranostics to Help Understand and Treat Reactive Oxygen Species Related Diseases.
K.-C. Yan, A. C. Sedgwick, Y. Zang, G.-R. Chen, X.-P. He*, J. Li*, J. Yoon*, T. D. James*
Small Methods 20193, 1900013.

A Fluorogenic 2D Glycosheet for the Simultaneous Identification of Human- and Avian-Receptor Specificity in Influenza Viruses.
J.-X. Song, X.-Y. Tang, D.-M. Zhou*, W. Zhang, T. D. James, X.-P. He*, He Tian
Mater. Horiz. 20174, 431-436.

Fluorogenic 2D Peptidosheet Unravels CD47 as a Potential Biomarker for Profiling Hepatocellular Carcinoma and Cholangiocarcinoma Tissues.
Y.-H. Ma, W.-T. Dou, Y.-F. Pan, L.-W. Dong, Y.-X. Tan, X.-P. He*, H. Tian, H.-Y. Wang*
Adv. Mater. 2017, 29, 1604253. (ESI highly cited paper; Inside back cover)

Targeted Intracellular Production of Reactive Oxygen Species by a 2D Molybdenum Disulfide Glycosheet.
D.-K. Ji, Y. Zhang, Y. Zang, J. Li*, G.-R. Chen, X.-P. He*, H. Tian
Adv. Mater. 2016, 28, 9356-9363. (ESI hot paper)

Photoluminescence Architectures for Disease Diagnosis: From Graphene to Thin-Layer Transition Metal Dichalcogenides and Oxides.
X.-P. He, H. Tian*
Small 2016, 12, 144-160. (ESI highly cited paper; Highlighted by MaterialsViews China)

Ratiometric Detection of β‐Amyloid and Discrimination from Lectins by a Supramolecular AIE Glyconanoparticle.
J.-D. Zhang, J. Mei, X.-L. Hu, X.-P. He*, H. Tian
Small 201612, 6562-6567.

Simultaneous Detection of Diverse Glycoligand-Receptor Recognitions Using a Single-Excitation, Dual-Emission Graphene Composite.
D.-K. Ji, G.-R. Chen, X.-P. He*, H. Tian
Adv. Funct. Mater. 201525, 3483-3487.

Fluorogenic Probing of Specific Recognitions between Sugar Ligands and Glycoprotein Receptors on Cancer Cells by an Economic Graphene Nanocomposite.
H.-L. Zhang, X.-L. Wei, Y. Zang, J.-Y. Cao, S. Liu, X.-P. He*, Q. Chen, Y.-T. Long, J. Li*, G.-R. Chen*, K. Chen
Adv. Mater. 2013, 25, 4097-4101. (Front cover)

Xiao-Peng He

Xiao-Peng He (Franck) received his BSc in Applied Chemistry (2006) and PhD in Pharmaceutical Engineering (2011) with Prof. Xiaoxin Shi and Prof. Yi-Tao Long from ECUST. Sponsored by the French Embassy, He completed a co-tutored doctoral program at ENS Cachan (France) from July 2008 to February 2009 under the supervision of Prof. Juan Xie. Then he carried out his postdoctoral research with Prof. Kaixian Chen (SIMM, CAS) at ECUST from 2011 to 2013. He’s now a professor at School of Chemistry and Molecular Engineering, ECUST, where his research interests span chemical glycobiology to fluorescent molecular probes for disease diagnostics and theranostics. Prof. He has co-authored over 100 peer-reviewed papers and is co-inventor of 8 Chinese patents.

Read More

Cover Gallery