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研究方向

医学为导向的化学生物学研究;课题组主要围绕以下两方面开展基础与应用研究:

  • 生物大分子动态修饰(尤其聚焦糖基化/去糖基化)的原位化学探测;

  • 人类重大疾病早期诊断试剂和糖靶向药研发。

Research Interest

Our research interest spans chemistry, biology, materials science and medical sciences, mainly focusing on the following two subjects:

  • Fluorescence-based molecular probes for precise biosensing and bioimaging.

  • Development of novel diagnostic and theranostic tools for human fatal diseases.

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课题组简介

贺晓鹏课题组研究方向跨化学、材料科学、生物学、临床医学等多个基础科学领域,与中科院上海药物研究所国家新药筛选中心,复旦大学附属中山医院,海军军医大学附属上海东方肝胆外科医院,上海交通大学药学院,上海交通大学附属仁济医院,天津医科大学,国家蛋白质中心,上海同步辐射光源,海军军医大学附属长海医院等国内顶尖生物医学团队建立跨学科合作平台,致力于培养、建立学生的交叉学科研究思维。诚挚欢迎对通过化学原理与技术探测生命与疾病过程中的关键科学问题,以及对研发具备我国自主知识产权,人类重大疾病诊治新试剂、新材料具有浓厚兴趣和探索精神的同学加入课题组!课题组培养硕、博研究生中已有多人获上海市和校级优秀博士学位论文,研究生国家奖学金和成思危校长奖等各类荣誉奖励,课题组培养博士、博士后已有1人留校任教,1人受聘中科院上海药物所青年PI。

招生专业

  • 博士第一招生专业:应用化学

  • 博士第二招生专业:精细合成化学与分子工程

  • 工程博士招生专业:生物与医药

  • 硕士第一招生专业:应用化学

  • 硕士第二招生专业:精细合成化学与分子工程

  • 工程硕士招生专业:制药工程

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Representative publications

Research Articles

A homogeneous high-throughput array for the detection and discrimination of influenza A viruses
W. Dou, X. Wang, T. Liu, S. Zhao, J. Liu, Y. Yan, J. Li, C. Zhang, A. C. Sedgwick, H. Tian, J. L. Sessler*, D. M. Zhou*, X.-P. He*
Chem. 20228, 1-12.

Tuning the Solid- and Solution-State Fluorescence of the Iron-Chelator Deferasirox.
X. L. Hu, A. C. Sedgwick*, D. N. Mangel, Y. Shang, A. Steinbrueck, K. Yan, L. Zhu, D. W. Snelson, S. Sen, C. V. Chau, G. Juarez, V. M. Lynch, X.-P. He*, J. L. Sessler*
J. Am. Chem. Soc.  2022144, 7382–7390.

Deferasirox (ExJade): An FDA-Approved AIEgen Platform with Unique Photophysical Properties.
A. C. Sedgwick, K.-C. Yan, D. N. Mangel, Y. Shang, A. Steinbrueck, H.-H. Han, J. T. Brewster II, X.-L. Hu, D. W. Snelson, V. M. Lynch, H. Tian, X.-P. He*, J. L. Sessler*
J. Am. Chem. Soc.  2021143, 1278-1283. (ESI highly cited paper)

Photochromic Fluorescent Probe Strategy for the Super-resolution Imaging of Biologically Important Biomarkers.
X. Chai, H.-H. Han, A. C. Sedgwick, N. Li, Y. Zang, T. D. James, J. Zhang*, X.-L. Hu, Y. Yu, Y. Li, Y. Wang, J. Li*, X.-P. He*, H. Tian
J. Am. Chem. Soc.  2020, 142, 18005-18013.

Cyclodextrin-Based Peptide Self-Assemblies (Spds) That Enhance Peptide-Based Fluorescence Imaging and Antimicrobial Efficacy.
J.-B. Jiao, G.-Z. Wang, X.-L. Hu, Y. Zang, S. Maisonneuve, A. C. Sedgwick, J. L. Sessler*, J. Xie*, J. Li*, X.-P. He*,  H. Tian
J. Am. Chem. Soc. 
2020, 142, 1925-1932.

A Supramolecular‐Based Dual‐Wavelength Phototherapeutic Agent with Broad Spectrum Antimicrobial Activity against Drug Resistant Bacteria.
Z.-H. Yu, X. Li, F. Xu, X.-L. Hu, J. Yan, N. Kwon, G.-R. Chen, T. Tang, X. Dong, Y. Mai*, D. Chen*, J. Yoon*, X.-P. He*, H. Tian
Angew. Chem. Int. Ed. 2020, 59, 3658-3664.

Self-assembled sialyllactosyl probes with aggregation-enhanced properties for ratiometric detection and blocking of influenza viruses.
W.-T. Dou, Z.-Y. Qin, J. Li, D.-M. Zhou, X.-P. He*
Sci. Bull. 2019, 64, 1902-1909.

An ESIPT Probe for the Ratiometric Imaging of Peroxynitrite Facilitated by Binding to Aβ-Aggregates.
A. C. Sedgwick, W.-T. Dou, J.-B. Jiao, L. Wu, G. T. Williams, A. T. A. Jenkins, S. D. Bull, J. L. Sessler*, X.-P. He*, T. D. James*
J. Am. Chem. Soc. 2018140, 14267-14271.

Photo-Controlled Fluorescence “Double-Check” Bioimaging Enabled by a Glycoprobe-protein Hybrid.
Y. Fu, H.-H. Han, J. Zhang*, X.-P. He*, B. L. Feringa, H. Tian*
J. Am. Chem. Soc. 2018, 140, 8671-8674.

Supramolecular Nanostructures of Structurally Defined Graphene Nanoribbons in Aqueous Phase.
Y. Huang, W.-T. Dou, F. Xu, H.-B. Ru, Q. Gong, D. Wu, D. Yan, H. Tian, X.-P. He*, Y. Mai*, X. Feng
Angew. Chem. Int. Ed. 2018, 57, 3366-3371. (Very Important Paper)

Remote Light-Controlled Intracellular Target Recognition by Photochromic Fluorescent Glycoprobes.
J. Zhang, Y. Fu, H.-H. Han, Y. Zang, J. Li*, X.-P. He*, B. L. Feringa, H. Tian*
Nat. Commun. 2017, 8, 987. (ESI highly cited paper; ESI hot paper; Highlighted by Sci. China Chem.)

Rapid Identification of the Receptor-Binding Specificity of Influenza A Viruses by Fluorogenic Glycofoldamers.
X.-P. He*, Y.-L. Zeng, X.-Y. Tang, N. Li, D.-M. Zhou*, G.-R. Chen, H. Tian*
Angew. Chem. Int. Ed. 2016, 55, 13995-13999. (ESI hot paper; Inside back cover)

Epimeric Monosaccharide-Quinone Hybrids on Gold Electrodes toward the Electrochemical Probing of Specific Carbohydrate–Protein Recognitions.
X.-P. He, X.-W. Wang, X.-P. Jin, H. Zhou, X.-X. Shi, G.-R. Chen, Y.-T. Long*
J. Am. Chem. Soc. 2011, 133, 3649-3657.

Multivalent Glycosheets for Double Light–Driven Therapy of Multidrug-Resistant Bacteria on Wounds.
X.-L. Hu, L. Chu, X. Dong, G.-R. Chen, T. Tang, D. Chen*, X.-P. He*, H. Tian
Adv. Funct. Mater. 201929, 1806986.

Fluorogenic 2D Peptidosheet Unravels CD47 as a Potential Biomarker for Profiling Hepatocellular Carcinoma and Cholangiocarcinoma Tissues.
Y.-H. Ma, W.-T. Dou, Y.-F. Pan, L.-W. Dong, Y.-X. Tan, X.-P. He*, H. Tian, H.-Y. Wang*
Adv. Mater. 2017, 29, 1604253. (ESI highly cited paper; Inside back cover)

Targeted Intracellular Production of Reactive Oxygen Species by a 2D Molybdenum Disulfide Glycosheet.
D.-K. Ji, Y. Zhang, Y. Zang, J. Li*, G.-R. Chen, X.-P. He*, H. Tian
Adv. Mater. 2016, 28, 9356-9363. (ESI hot paper)

Simultaneous Detection of Diverse Glycoligand-Receptor Recognitions Using a Single-Excitation, Dual-Emission Graphene Composite.
D.-K. Ji, G.-R. Chen, X.-P. He*, H. Tian
Adv. Funct. Mater. 201525, 3483-3487.

Fluorogenic Probing of Specific Recognitions between Sugar Ligands and Glycoprotein Receptors on Cancer Cells by an Economic Graphene Nanocomposite.
H.-L. Zhang, X.-L. Wei, Y. Zang, J.-Y. Cao, S. Liu, X.-P. He*, Q. Chen, Y.-T. Long, J. Li*, G.-R. Chen*, K. Chen
Adv. Mater. 2013, 25, 4097-4101. (Front cover)

Review Articles

Lightening up Membrane Receptors with Fluorescent Molecular Probes and Supramolecular Materials.
X.-P. He, H. Tian*
Chem 2018, 4, 246-268. (ESI highly cited paper; Invited review)

Fluorescent probes for the detection of disease-associated biomarkers.
W.-T. Dou, H.-H. Han, A. C. Sedgwick, G.-B. Zhu, Y. Zang, X.-R. Yang*, J. Yoon*, T. D. James*, J. Li*, X.-P. He*
Sci. Bull. 2022, 67, 853–878. (Invited review)

Fluorescent probes for the detection of chemical warfare agents
W.-Q. Meng†*, A. C. Sedgwick, N.Kwon, M. Sun, K. Xiao*, X.-P. He*, E. V. Anslyn*, T. D. James*, J. Yoon*
Chem. Soc. Rev. 2022

Small-molecule fluorescence-based probes for interrogating major organ diseases
H.-H. Han, H. Tian Jr., Y. Zang, A. C. Sedgwick, J. Li*, J. L. Sessler*, X.-P. He*, T. D. James*
Chem. Soc. Rev. 202150, 9391-9429.

Förster Resonance Energy Transfer (FRET)-Based Small-Molecule Sensors and Imaging Agents.
L. Wu, C. Huang*, B. P. Emery, A. C. Sedgwick, S. D. Bull, X.-P. He, H. Tian*, J. Yoon*, J. L. Sessler*, T. D. James*
Chem. Soc. Rev. 202049, 5110-5139.(ESI highly cited paper; ESI hot paper)

Transition Metal Chelators, Pro-Chelators, and Ionophores as Small Molecule Cancer Chemotherapeutic Agents.
A. Steinbrueck, A. C. Sedgwick, J. T. Brewster II, K.-C. Yan, Y. Shang, D. M. Knoll, G. I. Vargas-Zúñiga, X.-P. He*, H. Tian*, J. L. Sessler*
Chem. Soc. Rev. 202049, 3726-3747.

Metal-Based Imaging Agents: Progress towards Interrogating Neurodegenerative Disease.
A. C. Sedgwick, J. T. Brewster II, P. Harvey*, D. A. Iovan, G. Smith, X.-P. He*, H. Tian*, J. L. Sessler*, T. D. James*
Chem. Soc. Rev. 202049, 2886-2915.

Fluorescent Glycoconjugates and Their Applications.
B. Thomas, K.-C. Yan, X.-L. Hu, M. Donnier-Maréchal, G.-R. Chen*, X.-P. He*S. Vidal*
Chem. Soc. Rev. 2020, 49, 593-641.

Fluorogenic Probes for Disease-Relevant Enzymes.
J. Zhang, X. Chai, X.-P. He*, H.-J. Kim*, J. Yoon*, H. Tian
Chem. Soc. Rev. 201948, 683-722. (ESI highly cited paper)

Excited-State Intramolecular Proton-Transfer (ESIPT) Based Fluorescence Sensors and Imaging Agents.
A. C. Sedgwick, L. Wu, H.-H. Han, S. D. Bull*, X.-P. He*, T. D. James*, J. L. Sessler*, B.- Z. Tang*, H. Tian*, J. Yoon*
Chem. Soc. Rev. 2018, 47, 8842-8880. (ESI highly cited paper; ESI hot paper)

Multiplexed Photoluminescent Sensors: Towards Improved Disease Diagnostics.
X.-P. He*, X.-L. Hu, T. D. James*, J. Yoon*, H. Tian*
Chem. Soc. Rev. 2017, 46, 6687-6696. (Tutorial review)

Probing Disease-Related Proteins with Fluorogenic Composite Materials.
X.-P. He, Y. Zang, T. D. James, J. Li*, G.-R. Chen*
Chem. Soc. Rev. 2015, 44, 4239-4248. (ESI highly cited paper; Tutorial review)

Fluorescent probes for the imaging of lipid droplets in live cells.
H. Tian Jr., A. C. Sedgwick, H.-H. Han, S. Sen, G.-R. Chen, Y. Zang, J. L. Sessler*, T. D. James*, J. Li*, X.-P. He*
Coord. Chem. Rev. 2021, 427, 213577. (ESI highly cited paper)

Bio-Conjugated Advanced Materials for Targeted Disease Theranostics.
X.-L. Hu, N. Kwon, K.-C. Yan, A. C. Sedgwick, G.-R. Chen, X.-P. He*, T. D. James*, J. Yoon*
Adv. Funct. Mater. 2020, 30, 1907906.

Sensors, Imaging Agents, and Theranostics to Help Understand and Treat Reactive Oxygen Species Related Diseases.
K.-C. Yan, A. C. Sedgwick, Y. Zang, G.-R. Chen, X.-P. He*, J. Li*, J. Yoon*, T. D. James*
Small Methods 20193, 1900013.

Fluorescent Glycoprobes: A Sweet Addition for Improved Sensing.
X.-P. He, Y. Zang, T. D. James*, J. Li*, G.-R. Chen*, J. Xie*
Chem. Commun. 2017, 53, 82-90. (ESI highly cited paper; Feature article)

Photoluminescence Architectures for Disease Diagnosis: From Graphene to Thin-Layer Transition Metal Dichalcogenides and Oxides.
X.-P. He, H. Tian*
Small 2016, 12, 144-160. (ESI highly cited paper; Highlighted by MaterialsViews China)

Xiao-Peng He

Xiao-Peng He (Franck) received his BSc in Applied Chemistry (2006) and PhD in Pharmaceutical Engineering (2011) (Supervisor, Prof. Xiao-Xin Shi) from ECUST. Sponsored by the French Embassy, He completed a co-tutored doctoral program at ENS Cachan (France) from July 2008 to February 2009 under the supervision of Prof. Juan Xie. Then, he carried out his postdoctoral research with Prof. Kaixian Chen (SIMM, CAS) at ECUST from 2011 to 2013. He’s now a professor at the Feringa Nobel Prize Scientist Joint Research Centre, School of Chemistry and Molecular Engineering of ECUST, and a guest research fellow at the National Center for Liver Cancer, where his research interests span chemical glycobiology to fluorescent probes for disease diagnosis and imaging-guided therapy. Prof. He has co-authored over 180 peer-reviewed papers with a citation of 6500 (h-index 42) and is co-inventor of over 10 Chinese patents.

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